Segurança e Eficácia do Mepolizumab durante a Gravidez e Pós-Parto

Autores

  • Joana Marques Simões Department of Pulmonology. Unidade Local de Saúde Santa Maria. Lisbon. https://orcid.org/0000-0003-3756-4080
  • Daniela Vidal Department of Pulmonology. Hospital Guillermo Grant Benavante. Concepción.
  • Daniel Laorden Department of Pulmonology. Hospital Universitario La Paz. Madrid. https://orcid.org/0000-0001-9054-5925
  • Magdalena Lluch-Bernal Department of Allergy. Hospital Universitario La Paz. Institute for Health Research (IDIPAZ). Madrid. https://orcid.org/0000-0002-5815-5211
  • Javier Domínguez-Ortega Department of Allergy. Hospital Universitario La Paz. Institute for Health Research (IDIPAZ). Madrid. https://orcid.org/0000-0002-5397-2327

DOI:

https://doi.org/10.20344/amp.24222

Palavras-chave:

Anticorpos Monoclonais Humanizados, Asma/tratamento farmacológico, Antiasmáticos/tratamento farmacológico, Gravidez, Período Pós-Parto/efeitos dos fármacos

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Referências

Harrison T, Canonica GW, Chupp G, Lee J, Schleich F, Welte T, et al. Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis. Eur Respir J. 2020;56:2000151. DOI: https://doi.org/10.1183/13993003.00151-2020

European Medicines Agency. Nucala: sumary of product characteristics (SmPC). [cited 2026 Jan 10]. Available from: https://www.ema.europa.eu/en/documents/product-information/nucala-epar-product-information_en.pdf.

Vittorakis SK, Giannakopoulou G, Samitas K, Zervas E. Successful and safe treatment of severe steroid depended eosinophilic asthma with mepolizumab in a woman during pregnancy. Respir Med Case Rep. 2022;41:101785. DOI: https://doi.org/10.1016/j.rmcr.2022.101785

Jang W, Jo H, Park J, Kim S, Cho H, Jeong YD, et al. Use of biologics to treat asthma during pregnancy and adverse events in pregnant women and newborns: a global pharmacovigilance analysis. Int Arch Allergy Immunol. 2025;186:875-88. DOI: https://doi.org/10.1159/000543490

European Medicines Agency. The Mepolizumab Pregnancy Exposure Study: a VAMPSS post marketing surveillance study of Mepolizumab safety in pregnancy (200870 NPSS (Nucala Pregnancy Surveillance Study)). [cited 2025 Aug 16]. Available from: https://catalogues.ema.europa.eu/node/2613/administrative-details.

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Publicado

2026-03-02

Como Citar

1.
Marques Simões J, Vidal D, Laorden D, Lluch-Bernal M, Domínguez-Ortega J. Segurança e Eficácia do Mepolizumab durante a Gravidez e Pós-Parto. Acta Med Port [Internet]. 2 de Março de 2026 [citado 1 de Agosto de 2026];39(3):239-40. Disponível em: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/24222

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