Circulating Blood B and T Lymphocytes and Severity of Acute Pancreatitis: A Systematic Review Protocol

Filipa Malheiro; Margarida Leitão do Nascimento; Luís Miguel Borrego

doi:10.20344/amp.20087

Autores

Filipa Malheiro Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.
Margarida Leitão do Nascimento Serviço de Medicina Interna. Hospital da Luz. Lisboa.
Luís Miguel Borrego Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.

DOI:

https://doi.org/10.20344/amp.20087

Palavras-chave:

Linfócitos B, Linfócitos T, Pancreatite, Revisão Sistemática

Resumo

Introdução: A pancreatite aguda é uma doença inflamatória do pâncreas de elevada prevalência que pode evoluir com vários graus de gravidade e ser fatal. Muitos dos mecanismos que determinam a evolução e gravidade da pancreatite aguda ainda são desconhecidos. O objetivo principal desta revisão é identificar a potencial associação entre os níveis no sangue periférico dos linfócitos T e B e a gravidade da pancreatite aguda. Proceder-se-á também à análise por subgrupos de gravidade de acordo com os níveis de gravidade definidos pelo Revised Atlanta Classification System bem como a sua distinção de linfócitos T e linfócitos B.
Métodos: Será feita uma revisão sistemática na Medline, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials e ClinicalTrails.gov. Três revisores farão de forma independente a seleção dos estudos bem como a extração de dados que serão registados em diagrama proposto pelo Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). A pancreatite aguda é uma patologia com fisiopatologia ainda não totalmente esclarecida e evolução por vezes imprevisível. Neste contexto, através desta revisão sistemática a equipa de investigação pretende determinar o que há descrito sobre o papel dos linfócitos séricos na determinação da gravidade da pancreatite aguda, identificando um potencial indicador de gravidade desta doença aguda.

Downloads

Não há dados estatísticos.

Referências

Mederos MA, Reber HA, Girgis MD. Acute pancreatitis: a review. JAMA. 2021;325:382-90.

Del Vecchio Blanco G, Gesuale C, Varanese M, Monteleone G, Paoluzi OA. Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up. Clin J Gastroenterol. 2019;12:511-24.

Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, et al. Acute pancreatitis: diagnosis and treatment. Drugs. 2022;82:1251-76.

Lee PJ, Papachristou GI. New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16:479-96.

Barreto SG, Habtezion A, Gukovskaya A, Lugea A, Jeon C, Yadav D, et al. Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis. Gut. 2021;70:194-203.

Gukovskaya AS, Gukovsky I, Algül H, Habtezion A. Autophagy, inflammation, and in the pathogenesis of pancreatitis. Gastroenterology. 2017;153:1212-26.

Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62:102-11.

Walkowska J, Zielinska N, Tubbs RS, Podgórski M, Dłubek-Ruxer J, Olewnik Ł. Diagnosis and treatment of acute pancreatitis. Diagnostics. 2022;12:1974.

Wu BU, Batech M, Quezada M, Lew D, Fujikawa K, Kung J, et al. Dynamic measurement of disease activity in acute pancreatitis: the pancreatitis activity scoring system. Am J Gastroenterol. 2017;112:1144-52.

Peng Y, Zhu X, Hou C, Shi C, Huang D, Lu Z, et al. Development an inflammation-related factor-based model for predicting organ failure in acute pancreatitis: a retrospective cohort study. Mediators Inflamm. 2021;2021:4906768.

Zhao Z, Shen J, Zhang D, Shen J. The prognostic role of peripheral lymphocyte subsets in patients with acute pancreatitis. Am J Med Sci. 2019;357:242-6.

Bedel C, Korkut M, Selvi F. New markers in predicting the severity of acute pancreatitis in the emergency department: Immature granulocyte count and percentage. J Postgrad Med. 2021;67:7-11.

Deng LH, Hu C, Cai WH, Chen WW, Zhang XX, Shi N, et al. Plasma cytokines can help to identify the development of severe acute pancreatitis on admission. Medicine. 2017;96:e7312.

Wei X, Yao W, Li H, Qian J, Xie Y, Zhang Z, et al. B and NK cells closely correlate with the condition of patients with acute pancreatitis. Gastroenterol Res Pract. 2019;2019:7568410.

Qiu L, Zhou Y, Yu Q, Yu J, Li Q, Sun R. Decreased levels of regulatory B cells in patients with acute pancreatitis: association with the severity of the disease. Oncotarget. 2018;9:36067-82

Cao X, Wang HM, Lu R, Zhang XH, Qu YL, Wang L, et al. Establishment and verification of a nomogram for predicting severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2021;25:1455-61.

Huang L, Chen C, Yang L, Wan R, Hu G. Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell. J Clin Lab Anal. 2019;33:e22839.

Jeon TJ, Park JY. Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis. World J Gastroenterol. 2017;23:3883-9.

Buter A, Imrie CW, Carter CR, Evans S, McKay CJ. Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis. Br J Surg. 2002;89:298-302.

van den Berg FF, de Bruijn AC, van Santvoort HC, Issa Y, Boermeester MA. Early laboratory biomarkers for severity in acute pancreatitis; a systematic review and meta-analysis. Pancreatology. 2020;20:1302-11.

Gao W, Yang HX, Ma CE. The value of BISAP score for predicting mortality and severity in acute pancreatitis: a systematic review and meta-analysis. PLoS One. 2015;10:e0130412.

Basit H, Ruan GJ, Mukherjee S. Ranson criteria. 2023.

Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990;174:331-6.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and metaanalysis protocols (prisma-p) 2015: elaboration and explanation. BMJ. 2015;349:g7647.

Bhatia M, Fei LW, Cao Y, Lau HY, Huang J, Puneet P, et al. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5:132-44.

Zhang XP, Chen HQ, Liu F, Zhang J. Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis. J Zhejiang Univ Sci B. 2009;10:493-8.

Zhou Q, Tao X, Xia S, Guo F, Pan C, Xiang H, et al. T lymphocytes: a promising immunotherapeutic target for pancreatitis and pancreatic cancer? Front Oncol. 2020;10:382.

Pietruczuk M, Dabrowska MI, Wereszczynska-Siemiatkowska U, Dabrowski A. Alteration of peripheral blood lymphocyte subsets in acute pancreatitis. World J Gastroenterol. 2006;12:5344-51.

Guo J, Li Z, Tang D, Zhang J. Th17/Treg imbalance in patients with severe acute pancreatitis: attenuated by high-volume hemofiltration treatment. Medicine. 2020;99:e21491.

Wang M, Jiang Z, Liang H. Glucocorticoids in acute pancreatitis: a propensity score matching analysis. BMC Gastroenterol. 2021;21:331.