Circulating Blood B and T Lymphocytes and Severity of Acute Pancreatitis: A Systematic Review Protocol

Filipa Malheiro; Margarida Leitão do Nascimento; Luís Miguel Borrego

doi:10.20344/amp.20087

Autores

Filipa Malheiro Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.
Margarida Leitão do Nascimento Serviço de Medicina Interna. Hospital da Luz. Lisboa.
Luís Miguel Borrego Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.

DOI:

https://doi.org/10.20344/amp.20087

Palavras-chave:

Linfócitos B, Linfócitos T, Pancreatite, Revisão Sistemática

Resumo

Introdução: A pancreatite aguda é uma doença inflamatória do pâncreas de elevada prevalência que pode evoluir com vários graus de gravidade e ser fatal. Muitos dos mecanismos que determinam a evolução e gravidade da pancreatite aguda ainda são desconhecidos. O objetivo principal desta revisão é identificar a potencial associação entre os níveis no sangue periférico dos linfócitos T e B e a gravidade da pancreatite aguda. Proceder-se-á também à análise por subgrupos de gravidade de acordo com os níveis de gravidade definidos pelo Revised Atlanta Classification System bem como a sua distinção de linfócitos T e linfócitos B.
Métodos: Será feita uma revisão sistemática na Medline, Web of Science, EMBASE, Cochrane Central Register of Controlled Trials e ClinicalTrails.gov. Três revisores farão de forma independente a seleção dos estudos bem como a extração de dados que serão registados em diagrama proposto pelo Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). A pancreatite aguda é uma patologia com fisiopatologia ainda não totalmente esclarecida e evolução por vezes imprevisível. Neste contexto, através desta revisão sistemática a equipa de investigação pretende determinar o que há descrito sobre o papel dos linfócitos séricos na determinação da gravidade da pancreatite aguda, identificando um potencial indicador de gravidade desta doença aguda.

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