Subdural Hematoma in an Infant with Glutaric Aciduria Type 1: A Case Report on Conservative Management

Lúcia Marques; Patrícia Lipari Pinto; Hugo Loureiro Cadilha; Patrícia Janeiro; Ana Gaspar

doi:10.20344/amp.23093

Subdural Hematoma in an Infant with Glutaric Aciduria Type 1: A Case Report on Conservative Management

Authors

Lúcia Marques Pediatrics Department. Hospital Beatriz Ângelo. Loures. https://orcid.org/0000-0003-1853-6041
Patrícia Lipari Pinto Hereditary Metabolic Disease Reference Center. Pediatrics Department. Unidade Local de Saúde Santa Maria. Lisbon. https://orcid.org/0000-0001-9197-7586
Hugo Loureiro Cadilha Neurologic Imagiology Department. Unidade Local de Saúde Santa Maria. Lisbon. https://orcid.org/0009-0000-8921-0386
Patrícia Janeiro Hereditary Metabolic Disease Reference Center. Pediatrics Department. Unidade Local de Saúde Santa Maria. Lisbon. https://orcid.org/0000-0002-8985-1156
Ana Gaspar Hereditary Metabolic Disease Reference Center. Pediatrics Department. Unidade Local de Saúde Santa Maria. Lisbon. https://orcid.org/0000-0003-3979-9924

DOI:

https://doi.org/10.20344/amp.23093

Keywords:

Amino Acid Metabolism, Inborn Errors, Brain Diseases, Metabolic, Glutaryl-CoA Dehydrogenase, Infant, Hematoma, Subdural/therapy

Abstract

Glutaric aciduria type 1 is an inherited metabolic disorder associated with subdural hematomas, possibly due to the widening of external cerebrospinal fluid spaces. We present the case of an infant with macrocephaly since birth, diagnosed with glutaric aciduria type 1 through newborn screening, who exhibited accelerated cephalic growth during follow-up. At eight months of age, cranial magnetic resonance imaging revealed bilateral subdural hematomas with intracranial mass effect. The infant displayed no signs of intracranial hypertension, history of trauma, or signs of abuse. Although surgical treatment was considered, a multidisciplinary discussion led to the decision to manage conservatively with close monitoring. The patient remained clinically stable, and imaging showed a clear reduction in the dimensions of the hematomas. This case highlights that conservative management can be an effective approach for large subdural hematomas with mass effect in glutaric aciduria type 1, provided there is no associated symptomatology, thereby avoiding the risk of metabolic decompensation.

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References

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Published

2025-08-01

How to Cite

Marques L, Lipari Pinto P, Loureiro Cadilha H, Janeiro P, Gaspar A. Subdural Hematoma in an Infant with Glutaric Aciduria Type 1: A Case Report on Conservative Management. Acta Med Port [Internet]. 2025 Aug. 1 [cited 2025 Dec. 5];38(8):496-501. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/496-501

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Issue

Vol. 38 No. 8 (2025): August

Section

Case Report

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