Circulating Blood B and T Lymphocytes and Severity of Acute Pancreatitis: A Systematic Review Protocol


  • Filipa Malheiro Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.
  • Margarida Leitão do Nascimento Serviço de Medicina Interna. Hospital da Luz. Lisboa.
  • Luís Miguel Borrego Serviço de Medicina Interna. Hospital da Luz. Lisboa; NOVA Medical School. Universidade NOVA de Lisboa. Lisboa.



B-Lymphocytes, Pancreatitis, Systematic Review, T-Lymphocytes


Introduction: Acute pancreatitis is an acute inflammatory process of the pancreas with a high prevalence rate and varying degrees of severity that can be potentially life threatening. Much is still unknown about which mechanisms determine the course and severity of acute pancreatitis. The primary objective of this review is to identify the potential association between circulating B and T lymphocytes and the severity of acute pancreatitis. Subgroup analyses will be done according to the severity classification of the Revised Atlanta Classification System as well as according to the distinction between B lymphocytes and T lymphocytes and the severity of acute pancreatitis.
Methods: A systematic search will be performed in Medline, Web of Science, EMBASE, Cochrane Central Register of Controlled trials and Three authors will independently do the selection process as well as data extraction that will be recorded into a flow diagram following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The pathophysiology of acute pancreatitis is still not fully understood
and its evolution is sometimes unpredictable. In this context, through this systematic review, the research team intends to determine what has been described about the role of serum lymphocytes in determining the severity of acute pancreatitis, by identifying a potential indicator of the severity of this acute disease.


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How to Cite

Malheiro F, Leitão do Nascimento M, Miguel Borrego L. Circulating Blood B and T Lymphocytes and Severity of Acute Pancreatitis: A Systematic Review Protocol. Acta Med Port [Internet]. 2024 Apr. 1 [cited 2024 Apr. 23];37(4):274-9. Available from:



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