Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer

Authors

  • Andreia Tereso Serviço de Imagiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Luís Carreto Serviço de Pneumologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Manuela Baptista Serviço de Radiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Maria Amélia Almeida Serviço de Medicina Interna. Hospital Prof Doutor Fernando da Fonseca. Amadora.

DOI:

https://doi.org/10.20344/amp.9456

Keywords:

Carcinoma, Non-Small-Cell Lung/drug therapy, Crizotinib, Lung Diseases, Interstitial/chemically induced, Interstitial/diagnosis, Tomography, X-Ray Computed

Abstract

The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors. One example of tyrosine kinase inhibitors is crizotinib, an anaplastic lymphoma tyrosine kinase inhibitor, which targets an echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase gene fusion. This mutation is found in only 2% to 7% of non-small-cell lung cancer cases. Although these new therapies have shown promising results, the occurrence of interstitial lung disease as a side effect could be problematic. As the diagnosis of drug-related-interstitial lung disease is difficult to make, computed tomography is an important diagnostic tool. The recognition of computed tomography manifestations of tyrosine kinase inhibitors -induced interstitial lung disease is the key for an early recognition and management of this pulmonary toxicity. We aim to raise awareness of tyrosine kinase inhibitors-induced interstitial lung disease, by reporting the first case of a Portuguese patient treated with crizotinib for non-small-cell lung cancer who developed drug-induced interstitial lung disease.

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Author Biography

Andreia Tereso, Serviço de Imagiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.

Interna de Radiologia no Serviço de Imagiologia do Hospital Prof Doutor Fernando Fonseca, EPE

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Published

2019-03-29

How to Cite

1.
Tereso A, Carreto L, Baptista M, Almeida MA. Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer. Acta Med Port [Internet]. 2019 Mar. 29 [cited 2024 Mar. 1];32(3):236-9. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9456

Issue

Section

Case Report