Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer

Authors

  • Andreia Tereso Serviço de Imagiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Luís Carreto Serviço de Pneumologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Manuela Baptista Serviço de Radiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.
  • Maria Amélia Almeida Serviço de Medicina Interna. Hospital Prof Doutor Fernando da Fonseca. Amadora.

DOI:

https://doi.org/10.20344/amp.9456

Keywords:

Carcinoma, Non-Small-Cell Lung/drug therapy, Crizotinib, Lung Diseases, Interstitial/chemically induced, Interstitial/diagnosis, Tomography, X-Ray Computed

Abstract

The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors. One example of tyrosine kinase inhibitors is crizotinib, an anaplastic lymphoma tyrosine kinase inhibitor, which targets an echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase gene fusion. This mutation is found in only 2% to 7% of non-small-cell lung cancer cases. Although these new therapies have shown promising results, the occurrence of interstitial lung disease as a side effect could be problematic. As the diagnosis of drug-related-interstitial lung disease is difficult to make, computed tomography is an important diagnostic tool. The recognition of computed tomography manifestations of tyrosine kinase inhibitors -induced interstitial lung disease is the key for an early recognition and management of this pulmonary toxicity. We aim to raise awareness of tyrosine kinase inhibitors-induced interstitial lung disease, by reporting the first case of a Portuguese patient treated with crizotinib for non-small-cell lung cancer who developed drug-induced interstitial lung disease.

Downloads

Download data is not yet available.

Author Biography

Andreia Tereso, Serviço de Imagiologia. Hospital Prof Doutor Fernando da Fonseca. Amadora.

Interna de Radiologia no Serviço de Imagiologia do Hospital Prof Doutor Fernando Fonseca, EPE

Downloads

Published

2019-03-29

How to Cite

1.
Tereso A, Carreto L, Baptista M, Almeida MA. Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer. Acta Med Port [Internet]. 2019 Mar. 29 [cited 2024 Oct. 12];32(3):236-9. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9456

Issue

Section

Case Report