Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach

Authors

  • Paula Martins Serviço de Cardiologia Pediátrica. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
  • Eduardo Castela Serviço de Cardiologia Pediátrica. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
  • Graça Rocha Serviço de Pediatria Ambulatória. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
  • Cristina Sena Laboratório de Fisiologia. Instituto de Imagem Biomédica e Ciências da Vida (IBILI). Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
  • Raquel Seiça Laboratório de Fisiologia. Instituto de Imagem Biomédica e Ciências da Vida (IBILI). Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.

DOI:

https://doi.org/10.20344/amp.8726

Keywords:

Anti-Retroviral Agents, Atherosclerosis, Child, HIV Infections, Risk Factors

Abstract

Human immunodeficiency virus infected children and adolescents are a pediatric group with increased risk of premature cardiovascular disease. The virus itself, the antiretroviral therapy and the lifestyle establish a complex interplay of factors that promotes an accelerated atherosclerosis. This process is probably mediated by dyslipidaemia, dysregulation of glucose metabolism, lipodystrophy, inflammation, endothelial dysfunction and a prothrombotic state. The clinical approach to this population in terms of cardiovascular prevention is mainly based on efficient treatment of the infection, reduction of the modifiable risk factors and promotion of lifestyle changes.

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Published

2017-10-31

How to Cite

1.
Martins P, Castela E, Rocha G, Sena C, Seiça R. Premature Atherosclerosis in HIV-Infected Pediatric Patients: Literature Review and Clinical Approach. Acta Med Port [Internet]. 2017 Oct. 31 [cited 2023 Feb. 7];30(10):742-9. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/8726

Issue

Section

Review Articles