Primary amyloidosis associated with kappa light chain myeloma.

Authors

  • Raquel G Martins Serviço de Endocrinologia, Instituto Português de Oncologia do Porto, Porto.
  • Roberto Roncon-Albuquerque
  • Raquel Cabral
  • João Frazão
  • Pedro Von Hafe

DOI:

https://doi.org/10.20344/amp.603

Abstract

The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic echocardiogram did not reveal pathologic findings. Treatment initiation was complicated by hemodialysis catheter-associated Staphylococcus aureus infection.Primary amyloidosis associated with light chain myeloma is a rare, and often late, diagnosis with a dismal prognosis. Renal failure is a frequent initial presentation of the disease and infection an important cause of death.

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How to Cite

1.
Martins RG, Roncon-Albuquerque R, Cabral R, Frazão J, Von Hafe P. Primary amyloidosis associated with kappa light chain myeloma. Acta Med Port [Internet]. 2010 Apr. 14 [cited 2024 Mar. 29];23(2):281-4. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/603

Issue

Section

Arquivo Histórico