On jumbo and junkie trials: a fumbled affair, a jungle, or the ultimate solution?

Authors

  • P G Hugenholtz Department of Cardiology, Erasmus University, Rotterdam, Holland.

DOI:

https://doi.org/10.20344/amp.4484

Abstract

Important Clinical trials conducted between 1980 and 1990 provided early leads to the community of practicing cardiologists and general physicians on the fundamentals of the therapy of acute myocardial infarction. On the other hand trials like ISIS-III or GUSTO, the current giant among jumbo trials, could not solve the real problems arising in clinical practice. The large-scale clinical trials should be reserved for interventions that have been shown convincingly in smaller trials. The problem of restenosis after PTCA is discussed and the place of animal research is emphasized as the basis of the design of future clinical trials. These exciting data require a human study but with a scale that proves the efficacy of the intervention and substantiates the underlying hypothesis even in a small population.

Downloads

Download data is not yet available.

How to Cite

1.
Hugenholtz PG. On jumbo and junkie trials: a fumbled affair, a jungle, or the ultimate solution?. Acta Med Port [Internet]. 1991 Dec. 31 [cited 2024 Mar. 28];4:16S-8. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4484

Issue

Section

Arquivo Histórico