Effects of Intravenous Administration of Antigen on Lymphocyte Localization and Blood Flow into the Mouse Spleen.

A. A. Freitas; Benedita Rocha; J. Bognacki

doi:10.20344/amp.3784

Effects of Intravenous Administration of Antigen on Lymphocyte Localization and Blood Flow into the Mouse Spleen.

Authors

A. A. Freitas Departamento Imunologia, Faculdade de Ciências Médicas. Lisboa. Portugal Memorial Sloan Kettering Cancer Center. New York. USA
Benedita Rocha Departamento Imunologia, Faculdade de Ciências Médicas. Lisboa. Portugal Memorial Sloan Kettering Cancer Center. New York. USA
J. Bognacki Memorial Sloan Kettering Cancer Center. New York. USA

DOI:

https://doi.org/10.20344/amp.3784

Abstract

The present paper investigates whether the increased lymphocyte localization into the spleen, which occurs early after the i.v. injection of some antigens, is related to an increase in the blood flow to that organ. For this purpose the fractional distribution of cardiac output to the spleen using the ⁸⁶Rb Cl method, was studied at different intervals after the i.v. administration of agents known to be able to induce strong trapping. The results show no correlation between the accumulation of recirculating cells into the spleen and changes in blood flow.

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How to Cite

Freitas AA, Rocha B, Bognacki J. Effects of Intravenous Administration of Antigen on Lymphocyte Localization and Blood Flow into the Mouse Spleen. Acta Med Port [Internet]. 1983 Mar. 30 [cited 2024 Apr. 19];4(3):147-50. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3784

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Issue

Vol. 4 No. 3 (1983): Março

Section

Arquivo Histórico

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