Endocarditis caused by Candida parapsilosis after total correction of tetralogy of Fallot. Medico-surgical treatment.

A Macedo, A Agualusa, S Kaku, M Lima, J Cabrita, R Bento, F Sampayo


Three children with Candida Parapsilosis endocarditis after total surgical correction for Tetralogy of Fallot, are reported. Blood cultures became negative in one child with amphotericin-B and in the other two with Ketoconazole, before reoperation for septal patch replacement. Oral therapy with Ketoconazole continued for a total of 24 months, and during a mean follow-up of 36 months no side effects or reinfection occurred. Medical and surgical conjoined therapy, with surgical timing decided on clinical and laboratorial grounds, were important for good results and cure.

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