Essential thrombocythemia. Apropos a case of cerebrovascular stroke.

Authors

  • A S Oliveira Serviço de Medicina I, Hospital Universitário de Santa Maria, Lisboa.
  • M P Miranda
  • P C Duarte
  • J N Sarmento

DOI:

https://doi.org/10.20344/amp.3143

Abstract

The authors report the case of a 60-year-old white man with a previous history of pulmonary tuberculosis, smoking habits, hypertension, intermittent claudication and erythromelalgia, admitted to our ward with an ischemic cerebral event. Initial laboratory evaluation documented thrombocytosis (platelet-950000/mm3) and discrete anemia. Additional studies confirmed the diagnosis of essential thrombocythemia, meeting all the criteria proposed by the Polycythemia Vera Study Group in 1986, after exclusion of the possible causes of reactive thrombocytosis. Therapy was initiated with alpha-2b interferon (3 MU/m2 subcutaneously three times a week) and aspirin. Platelet count control was obtained and the patient remained asymptomatic. Nine months later cutaneous toxicity obliged the discontinuance of alpha-interferon. Due to a continuous increase of platelet count, hydroxyurea was introduced. The patient is asymptomatic, with platelet counts < 500000/mm3, without toxicity manifestations, two years after diagnosis. The contribution of cardiovascular risk factors versus thrombocythemia in the pathogenesis of the ischemic cerebral event and the benefit of platelet count control are discussed.

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How to Cite

1.
Oliveira AS, Miranda MP, Duarte PC, Sarmento JN. Essential thrombocythemia. Apropos a case of cerebrovascular stroke. Acta Med Port [Internet]. 1993 Oct. 30 [cited 2023 Feb. 4];6(10):461-5. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3143

Issue

Section

Arquivo Histórico