Alcohol and free oxygen radicals.

Authors

  • M L Mira Instituto de Química Fisiológica, Faculdade de Medicina, Lisboa.
  • C F Manso

DOI:

https://doi.org/10.20344/amp.3075

Abstract

Oxygen free radicals may be generated during ethanol metabolization by cytochrome P450, or due to the formation of xanthine oxidase by ethanol effect on xanthine dehydrogenase. After transformation into acetaldehyde, the metabolism of this compound by xanthine oxidase or by aldehyde oxidase also generates oxygen radicals. We present the hypothesis of a vicious cycle during ethanol metabolization by aldehyde oxidase, which would amplify the process and be responsible for an increased degree of lipid peroxidation.

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How to Cite

1.
Mira ML, Manso CF. Alcohol and free oxygen radicals. Acta Med Port [Internet]. 1993 May 30 [cited 2024 Mar. 29];6(5):193-8. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3075

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Arquivo Histórico