Bone marrow transplantation with major ABO incompatibility. Experience of the Bone Marrow Transplantation Unit--Francisco Gentil Portuguese Institute of Oncology, Lisbon Centre.

Authors

  • Rui Coelho Santa Maria Hospital Immuno-Hemotherapy Department, Francisco Gentil Portuguese Oncology Institute, Lisbon Centre.
  • Isabel Cunha
  • Inês Nolasco
  • Alexandre Machado
  • Manuel Abecassis

DOI:

https://doi.org/10.20344/amp.3034

Abstract

Thirteen patients submitted to bone marrow transplantation (BMT), HLA A and B identical, with mixed negative lymphocyte culture and major ABO incompatibility were retrospectively evaluated. Gravity sedimentation by hydroxyethyl starch was used in almost all cases to deplete erythrocytes from bone marrow (12/13): a removal rate of 90%--corresponding to an erythrocyte residual volume of 27,4 rate ml--and a nucleated cell recovery of 76% (mean values) were obtained. All patients underwent a hyperhydration regimen and received corticosteroid prophylaxis before bone marrow infusion. Considering the most important immunohematological problems associated to this type of transplant, we verified that seven patients developed minor complications and among them only one had long term consequences. In comparison with the control group, ABO identical and with minor incompatibility, the study group had delayed onset of erythropoiesis and needed greater erythrocyte transfusion support. We concluded that major ABO incompatibility does not constitute a drawback to BMT success in most patients.

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How to Cite

1.
Coelho R, Cunha I, Nolasco I, Machado A, Abecassis M. Bone marrow transplantation with major ABO incompatibility. Experience of the Bone Marrow Transplantation Unit--Francisco Gentil Portuguese Institute of Oncology, Lisbon Centre. Acta Med Port [Internet]. 1994 Dec. 31 [cited 2024 Mar. 1];7:S21-S24. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3034

Issue

Section

Arquivo Histórico