Subacute Combined Degeneration as the Initial Manifestation of Folate Deficiency

Joana Sousa Varela; Patrícia Ramos Santos; Miguel Simões Rodrigues; Mário Amaro; Maria Francisca Delerue

doi:10.20344/amp.24329

Subacute Combined Degeneration as the Initial Manifestation of Folate Deficiency

Authors

Joana Sousa Varela Internal Medicine Department. Hospital Garcia de Orta. Almada. https://orcid.org/0009-0000-4665-3590
Patrícia Ramos Santos Internal Medicine Department. Hospital Garcia de Orta. Almada. https://orcid.org/0009-0000-1078-0002
Miguel Simões Rodrigues Internal Medicine Department. Hospital Garcia de Orta. Almada. https://orcid.org/0009-0001-2544-392X
Mário Amaro Internal Medicine Department. Hospital Garcia de Orta. Almada. https://orcid.org/0000-0002-4958-4743
Maria Francisca Delerue Internal Medicine Department. Hospital Garcia de Orta. Almada. https://orcid.org/0000-0003-0570-0818

DOI:

https://doi.org/10.20344/amp.24329

Keywords:

Folic Acid Deficiency, Peripheral Nervous System Diseases, Subacute Combined Degeneration

Abstract

n/a.

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References

Saji AM, Lui F, De Jesus O. Spinal cord subacute combined degeneration. Treasure Island: StatPearls Publishing; 2024.

Guntupalli L, Lurie A, Stoll V, Lugo LD. A rare case of folate deficiency-induced subacute combined degeneration of the spinal cord: a case report. Cureus. 2023;15:e42593. DOI: https://doi.org/10.7759/cureus.42593

Taverner T, Crowe FL, Thomas GN, Gokhale K, Thayakaran R, Nirantharakumar K, et al. Circulating folate concentrations and risk of peripheral neuropathy and mortality: a retrospective cohort study in the U.K. Nutrients. 2019;11:2443. DOI: https://doi.org/10.3390/nu11102443

Holroyd KB, Berkowitz AL. Metabolic and toxic myelopathies. Continuum. 2024;30:199-223. DOI: https://doi.org/10.1212/CON.0000000000001376

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Published

2026-06-01

How to Cite

Sousa Varela J, Ramos Santos P, Simões Rodrigues M, Amaro M, Delerue MF. Subacute Combined Degeneration as the Initial Manifestation of Folate Deficiency. Acta Med Port [Internet]. 2026 Jun. 1 [cited 2026 Jun. 5];39(6-7):431-2. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/24329

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Issue

Vol. 39 No. 6-7 (2026): June-July

Section

Letters to the Editor

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