Monoclonal antibodies. General approach and radioimmunotherapy.

Authors

  • O Sousa Departamento de Radioterapia, Instituto Português de Oncologia, Porto.
  • E Vieira

DOI:

https://doi.org/10.20344/amp.2242

Abstract

Two major obstacles to systemic cancer therapy are the lack of specificity of therapeutic modalities and the intrapatient and interpatient heterogeneity of cancer cells. Because of their natural specificity, antibodies directed against tumor specific or tumor associated antigens have been raising interest in oncology. This article makes an overview of the basic principles of monoclonal antibodies, their limitations and perspectives, with particular attention to Immunoradioconjugates. The most important Immunoradiotherapy clinical studies are also reviewed.

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How to Cite

1.
Sousa O, Vieira E. Monoclonal antibodies. General approach and radioimmunotherapy. Acta Med Port [Internet]. 1998 Apr. 30 [cited 2024 Mar. 29];11(4):337-47. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2242

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Section

Arquivo Histórico