Clinical Update on Diagnosis, Treatment and Prevention of Dengue

Authors

  • Jorge B.A. Seixas Unidade de Ensino e Investigação de Clínica Tropical. Instituto de Higiene e Medicina Tropical. Universidade NOVA de Lisboa. Lisboa.
  • Kleber Giovanni Luz Departamento de Infectologia. Instituto de Medicina Tropical da Universidade Federal do Rio Grande do Norte. Hospital Giselda Trigueiro. Rio Grande do Norte.
  • Vitor Laerte Pinto Junior Clínica Universitária de Doenças Infeciosas. Faculdade de Medicina. Universidade de Lisboa.

DOI:

https://doi.org/10.20344/amp.20569

Keywords:

Dengue/diagnosis, Dengue/prevention and control, Dengue/therapy, Dengue Vaccines, Dengue Virus, Severe Dengue

Abstract

Dengue is a vector-borne disease that has a significant impact on global public health. The vector mosquito belongs to the genus Aedes. Two species play a key role in human transmission: Ae. aegypti, which has adapted to the urban environment of highly populated areas in tropical and subtropical countries, leading to a dramatic increase in dengue cases over the years, and Ae. albopictus, which poses a potential threat to temperate climate countries due to its ability to adapt to colder climates. The disease is widespread across the world, posing a risk to nearly half of the world’s population. Although most cases are asymptomatic, dengue causes a burden on healthcare systems and mainly affects the younger population. The disease is also spreading to temperate climate countries, thus becoming a global threat. Vector control measures and vaccine development have been the main prevention strategies, as there is still no effective treatment for the disease.

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References

Wilder-Smith A, Ooi EE, Horstick O, Wills B. Dengue. Lancet. 2019;393:350-63. DOI: https://doi.org/10.1016/S0140-6736(18)32560-1

Tian N, Zheng JX, Guo ZY, Li LH, Xia S, Lv S, et al. Dengue incidence trends and its burden in major endemic regions from 1990 to 2019. Trop Med Infect Dis. 2022;7:180. DOI: https://doi.org/10.3390/tropicalmed7080180

World Health Organization. Dengue and severe dengue. [consultado 2023 jul 12]. Disponível em: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.

Beatty ME, Beutels P, Meltzer MI, Shepard DS, Hombach J, Hutubessy R, et al. Health economics of dengue: a systematic literature review and expert panel’s assessment. Am J Trop Med Hyg. 2011;84:473-88. DOI: https://doi.org/10.4269/ajtmh.2011.10-0521

Gubler DJ, Meltzer M. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv Virus Res. 1999;53:35-70. DOI: https://doi.org/10.1016/S0065-3527(08)60342-5

Buchs A, Conde A, Frank A, Gottet C, Hedrich N, Lovey T, et al. The threat of dengue in Europe. New Microbes New Infect. 2022;49-50:101061. DOI: https://doi.org/10.1016/j.nmni.2022.101061

Wilder-Smith A, Gubler DJ. Geographic expansion of dengue: the impact of international travel. Med Clin North Am. 2008;92:1377-90. DOI: https://doi.org/10.1016/j.mcna.2008.07.002

Paupy C, Delatte H, Bagny L, Corbel V, Fontenille D. Aedes albopictus, an arbovirus vector: from the darkness to the light. Microbes Infect. 2009;11:1177-85. DOI: https://doi.org/10.1016/j.micinf.2009.05.005

Schaffner F, Mathis A. Dengue and dengue vectors in the WHO European region: past, present, and scenarios for the future. Lancet Infect Dis. 2014;14:1271-80. DOI: https://doi.org/10.1016/S1473-3099(14)70834-5

Kariyawasam R, Lachman M, Mansuri S, Chakrabarti S, Boggild AK. A dengue vaccine whirlwind update. Ther Adv Infect Dis. 2023;10:20499361231167274. DOI: https://doi.org/10.1177/20499361231167274

Gubler DJ, Ooi EE, Vasudevan S, Farrar J. Dengue and dengue hemorrhagic fever. 2nd ed. Boston: CABI; 2014. p.606. DOI: https://doi.org/10.1079/9781845939649.0000

Murugesan A, Manoharan M. Dengue virus. Emerging and reemerging viral pathogens. 2020;281-359. DOI: https://doi.org/10.1016/B978-0-12-819400-3.00016-8

Fried JR, Gibbons RV, Kalayanarooj S, Thomas SJ, Srikiatkhachorn A, Yoon IK, et al. Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006. PLOS Negl Trop Dis. 2010;4:e617. DOI: https://doi.org/10.1371/journal.pntd.0000617

Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;8:S7-16. DOI: https://doi.org/10.1038/nrmicro2460

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504-7. DOI: https://doi.org/10.1038/nature12060

Rigau-Pérez JG. Severe dengue: the need for new case definitions. Lancet Infect Dis. 2006;6:297-302. DOI: https://doi.org/10.1016/S1473-3099(06)70465-0

Horstick O, Tozan Y, Wilder-Smith A. Reviewing dengue: still a neglected tropical disease? PLoS Negl Trop Dis. 2015;9:e0003632. DOI: https://doi.org/10.1371/journal.pntd.0003632

Simmons CP, Farrar JJ, van Vinh Chau N, Wills B. Dengue. New Eng J Med. 2012;366:1423-32. DOI: https://doi.org/10.1056/NEJMra1110265

Tomasello D, Schlagenhauf P. Chikungunya and dengue autochthonous cases in Europe, 2007–2012. Travel Med Infect Dis. 2013;11:274-84. DOI: https://doi.org/10.1016/j.tmaid.2013.07.006

Alves MJ, Fernandes PL, Amaro F, Osório H, Luz T, Parreira P, et al. Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012. Euro Surveill. 2013;18:20398. DOI: https://doi.org/10.2807/ese.18.06.20398-en

Powell JR, Tabachnick WJ. History of domestication and spread of Aedes aegypti - a review. Mem Inst Oswaldo Cruz. 2013;108:11-7. DOI: https://doi.org/10.1590/0074-0276130395

Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microb Rev. 1998;11:480-96. DOI: https://doi.org/10.1128/CMR.11.3.480

Jansen CC, Beebe NW. The dengue vector Aedes aegypti: what comes next. Microbes Infect. 2010;12:272-9. DOI: https://doi.org/10.1016/j.micinf.2009.12.011

Consoli RA, Oliveira RL de. Principais mosquitos de importância sanitária no Brasil. Editora FIOCRUZ; 1994. [consultado 2023 jul 08]. Disponível em: https://books.scielo.org/id/th. DOI: https://doi.org/10.7476/9788575412909

Marabuto E, Rebelo MT. The Asian tiger mosquito, Aedes albopictus (Skuse, 1894), a vector of dengue, chikungunya and zika, reaches Portugal. bioRxiv; 2017: 192575. [consultado 2023 out 06]. Disponível em: https://www.biorxiv.org/content/10.1101/192575v1. DOI: https://doi.org/10.1101/192575

Barzon L, Gobbi F, Capelli G, Montarsi F, Martini S, Riccetti S, et al. Autochthonous dengue outbreak in Italy 2020: clinical, virological and entomological findings. J Travel Med. 2021;28:taab130. DOI: https://doi.org/10.1093/jtm/taab130

Reiter P. Yellow fever and dengue: a threat to Europe? Eurosurveill. 2010;15:19509. DOI: https://doi.org/10.2807/ese.15.10.19509-en

Centro de Estudos de Vetores e Doenças Infeciosas Doutor Francisco Cambournac. Relatório REVIVE 2022 - Culicídeos e Ixodídeos: Rede de Vigilância de Vetores. Instituto Nacional de Saúde Doutor Ricardo Jorge; 2023. [consultado 2023 out 06]. Disponível em: http://repositorio.insa.pt/handle/10400.18/8611.

Coffey LL, Mertens E, Brehin AC, Fernandez-Garcia MD, Amara A, Després P, et al. Human genetic determinants of dengue virus susceptibility. Microbes Infect. 2009;11:143-56. DOI: https://doi.org/10.1016/j.micinf.2008.12.006

Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, et al. Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg. 2001;65:180-3. DOI: https://doi.org/10.4269/ajtmh.2001.65.180

Clyde K, Kyle JL, Harris E. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol. 2006;80:11418-31. DOI: https://doi.org/10.1128/JVI.01257-06

Oliveira M, Saraiva DP, Cavadas B, Fernandes V, Pedro N, Casademont I, et al. Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease. Infect Genet Evol. 2018;62:60-72. DOI: https://doi.org/10.1016/j.meegid.2018.04.018

Halstead SB. Dengue antibody-dependent enhancement: knowns and unknowns. Microbiol Spectr. 2014;2. DOI: https://doi.org/10.1128/microbiolspec.AID-0022-2014

OhAinle M, Balmaseda A, Macalalad AR, Tellez Y, Zody MC, Saborío S, et al. Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. Sci Transl Med. 2011;3:114ra128. DOI: https://doi.org/10.1126/scitranslmed.3003084

Bulugahapitiya U, Siyambalapitiya S, Seneviratne SL, Fernando DJ. Dengue fever in travellers: a challenge for European physicians. Eur J Intern Med. 2007;18:185-92. DOI: https://doi.org/10.1016/j.ejim.2006.12.002

Oishi K, Saito M, Mapua CA, Natividad FF. Dengue illness: clinical features and pathogenesis. J Infect Chem. 2007;13:125-33. DOI: https://doi.org/10.1007/s10156-007-0516-9

Pan American Health Organization. Guidelines for the clinical diagnosis and treatment of dengue, chikungunya, and zika. 2022. [consultado 2023 jul 22]. Disponível em: https://iris.paho.org/handle/10665.2/55867.

Solomon T, Dung NM, Vaughn DW, Kneen R, Thao LT, Raengsakulrach B, et al. Neurological manifestations of dengue infection. Lancet. 2000;355:1053-9. DOI: https://doi.org/10.1016/S0140-6736(00)02036-5

World Health Organization. Dengue guidelines for diagnosis, treatment, prevention and control : new edition. 2009. [consultado 2023 jun 24]. Disponível em: https://apps.who.int/iris/handle/10665/44188.

Vasikasin V, Rojdumrongrattana T, Chuerboonchai W, Siriwiwattana T, Thongtaeparak W, Niyasom S, et al. Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial. Lancet Global Health. 2019;7:e664-70. DOI: https://doi.org/10.1016/S2214-109X(19)30032-4

Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181:2-9. DOI: https://doi.org/10.1086/315215

Peeling RW, Artsob H, Pelegrino JL, Buchy P, Cardosa MJ, Devi S, et al. Evaluation of diagnostic tests: dengue. Nat Rev Microbiol. 2010;8:S30-7. DOI: https://doi.org/10.1038/nrmicro2459

Raafat N, Blacksell SD, Maude RJ. A review of dengue diagnostics and implications for surveillance and control. Trans R Soc Trop Med Hyg. 2019;113:653-60. DOI: https://doi.org/10.1093/trstmh/trz068

Lim JK, Alexander N, Di Tanna GL. A systematic review of the economic impact of rapid diagnostic tests for dengue. BMC Health Services Research. 2017;17:850. DOI: https://doi.org/10.1186/s12913-017-2789-8

Muller DA, Depelsenaire AC, Young PR. Clinical and laboratory diagnosis of dengue virus infection. J Infect Dis. 2017;215:S89-95. DOI: https://doi.org/10.1093/infdis/jiw649

Pal S, Dauner AL, Mitra I, Forshey BM, Garcia P, Morrison AC, et al. Evaluation of dengue ns1 antigen rapid tests and ELISA kits using clinical samples. PLOS ONE. 2014;9:e113411. DOI: https://doi.org/10.1371/journal.pone.0113411

Osorio L, Ramirez M, Bonelo A, Villar LA, Parra B. Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection. Virol J. 2010;7:361. DOI: https://doi.org/10.1186/1743-422X-7-361

Teles FR, Prazeres DM, Lima-Filho JL. Trends in dengue diagnosis. Rev Medl Virol. 2005;15:287-302. DOI: https://doi.org/10.1002/rmv.461

Tully D, Griffiths CL. Dengvaxia: the world’s first vaccine for prevention of secondary dengue. Ther Adv Vaccines Immunother. 2021;9:25151355211015839. DOI: https://doi.org/10.1177/25151355211015839

Sridhar S, Luedtke A, Langevin E, Zhu M, Bonaparte M, Machabert T, et al. Effect of dengue serostatus on dengue vaccine safety and efficacy. N Engl J Med. 2018;379:327-40. DOI: https://doi.org/10.1056/NEJMoa1800820

Mallapaty S. Dengue vaccine poised for roll-out but safety concerns linger. Nature. 2022;611:434-5. DOI: https://doi.org/10.1038/d41586-022-03546-2

Thomas SJ. Is new dengue vaccine efficacy data a relief or cause for concern? Npj Vaccines. 2023;8:1-6. DOI: https://doi.org/10.1038/s41541-023-00658-2

Rivera L, Biswal S, Sáez-Llorens X, Reynales H, López-Medina E, Borja-Tabora C, et al. Three-year efficacy and safety of takeda’s dengue vaccine candidate (TAK-003). Clin Infect Dis. 2022;75:107-17. DOI: https://doi.org/10.1093/cid/ciab864

Castro M, Sánchez L, Pérez D, Carbonell N, Lefèvre P, Vanlerberghe V, et al. A community empowerment strategy embedded in a routine dengue vector control programme: a cluster randomised controlled trial. Trans R Soc Trop Med Hyg. 2012;106:315-21. DOI: https://doi.org/10.1016/j.trstmh.2012.01.013

Published

2024-02-01

How to Cite

1.
B.A. Seixas J, Giovanni Luz K, Pinto Junior V. Clinical Update on Diagnosis, Treatment and Prevention of Dengue. Acta Med Port [Internet]. 2024 Feb. 1 [cited 2024 Apr. 23];37(2):126-35. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/20569

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Review Articles