Not all Nodules Are Cancer and not all Fungal Infections Are Aspergillus
Keywords:Fungi, Humans, Lung Diseases, Fungal, Solitary Pulmonary Nodules
AbstractPithomyces, a dematiaceous fungus, is a common colonizer of dead leaves and stems of many different plants and is associated with facial eczema in some animals. We report a case of invasive fungal pulmonary disease by Pithomyces chartarum in a healthy, nonimmunocompromised patient. We aim to demonstrate our diagnostic and therapeutic approach and focus on the major challenges arising from the lack of scientific evidence regarding infection by this fungus in humans.
Webster J, Weber R. Introduction to Fungi. 3rd ed. Cambridge: Cambridge University Press; 2007.
Terada M, Ohki E, Yamagishi Y, Nishiyama Y, Satoh K, Uchida K, et al. Fungal peritonitis associated with Curvularia geniculata and Pithomyces species in a patient with vulvar cancer who was successfully treated with oral voriconazole. J Antibiot. 2014;67:191-3.
Cuttance EL, Stevenson MA, Laven RA, Mason WA. Facial eczema management protocols used on dairy farms in the North Island of New Zealand and associated concentrations of zinc in serum. N Z Vet J. 2016;64:343-50.
Pinto C, Santos VM, Dinis J, Peleteiro MC, Fitzgerald JM, Hawkes AD, et al. Pithomycotoxicosis (facial eczema) in ruminants in the Azores, Portugal. Vet Rec. 2005;157:805-10.
Schweigert M, Dubecz A, Beron M, Ofner D, Stein HJ. Pulmonary infections imitating lung cancer: clinical presentation and therapeutical approach. Ir J Med Sci. 2013;182:73-80.
Gazzoni FF, Severo LC, Marchiori E, Irion KL, Guimaraes MD, Godoy MC, et al. Fungal diseases mimicking primary lung cancer: radiologicpathologic correlation. Mycoses. 2014;57:197-208.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, et al. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect. 2018;24 Suppl 1:e1-e38.
Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020;71:1367-76.
Oliveira M, Delgado L, Ribeiro H, Abreu I. Fungal spores from Pleosporales in the atmosphere of urban and rural locations in Portugal. J Environ Monit. 2010;12:1187-94.
da Cunha KC, Sutton DA, Gene J, Cano J, Capilla J, Madrid H, et al. Pithomyces species (Montagnulaceae) from clinical specimens: identification and antifungal susceptibility profiles. Med Mycol. 2014;52:748-57.
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