Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population

Authors

  • Sara Moura Cabral Pulmonology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra. https://orcid.org/0000-0002-1392-7054
  • Inês Abreu Radiology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Daniela Madama Pulmonology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Amélia Estevão Radiology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Eugénio Cordeiro Department of Public Health. Administração Regional de Saúde do Centro. Coimbra.
  • João Pimentel Department of Public Health. Administração Regional de Saúde do Centro. Coimbra.
  • Nuno Miranda Haematology Department. Instituto Português de Oncologia de Lisboa. National Programme for Oncological Diseases. Lisboa.
  • António Jorge Ferreira Pulmonology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra.
  • Carlos Robalo Cordeiro Pulmonology Department. Centro Hospitalar e Universitário de Coimbra. Coimbra.

DOI:

https://doi.org/10.20344/amp.16847

Keywords:

Early Detection of Cancer, Lung Neoplasms/diagnostic imaging, Tobacco/adverse effects, Tomography, X-Ray Computed, Uranium/adverse effects

Abstract

Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk.
Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up.
Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion.
Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country.

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Published

2023-09-01

How to Cite

1.
Moura Cabral S, Abreu I, Madama D, Estevão A, Cordeiro E, Pimentel J, Miranda N, Ferreira AJ, Robalo Cordeiro C. Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population. Acta Med Port [Internet]. 2023 Sep. 1 [cited 2024 May 28];36(9):559-66. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16847

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