Macroprolactinemia--laboratory determination and its clinical significance.

Authors

  • Catarina Matos Interna de Endocrinologia, Serviço de Endocrinologia, Hospital de Braga, Braga, Portugal.
  • Marias Lopes Pereira
  • João Tiago Guimarães

DOI:

https://doi.org/10.20344/amp.1575

Abstract

Since prolactin (PRL) (a hormone produced by the anterior pituitary) was first identificated, the existence of hyperprolactinemic syndrome has been recognized. Main symptoms are galactorrhea, oligomenorrhea, amenorrhea and infertility in women and decreased libido and impotence in men. Macroprolactinemia reflects the predominance of circulating forms with reduced bioactivity not associated with typical clinical manifestations of hyperprolactinemia. It is identified by immunoassays commonly used in clinical practice, resulting in hyperprolactinemia. Polyetilenoglycol (PEG) is the most used method that removes PRL from serum. It is likely that the phenomenon of macroprolactinemia is consistently underestimated and unrecognized. Manufacturers of immunoassays for PRL have been slow to incorporate in the literature, validated protocols, and data related to the interference of PEG. From a clinical and biochemical point of view and, the main concern should be to avoid unnecessary investigation and treatment.

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How to Cite

1.
Matos C, Pereira ML, Guimarães JT. Macroprolactinemia--laboratory determination and its clinical significance. Acta Med Port [Internet]. 2011 Dec. 31 [cited 2024 Mar. 29];24:929-38. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1575

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Section

Arquivo Histórico