Hypoprothrombinemia--lupus anticoagulant syndrome.

Authors

  • Maria Manuel Campos Serviço de Imuno-Hemoterapia, Hospital de Curry Cabral, Lisbon, Portugal.
  • Isabel Reis Santos

DOI:

https://doi.org/10.20344/amp.1556

Abstract

Diagnosis criteria, pathogenic mechanisms, incidence and prevalence of the Antiphospholipid Syndrome are focused in a brief review. Hypoprothrombinemia (HPT) may be hereditary or acquired; the first is rare and with recessive autossomic transmission. We report the case of a 66-year-old white woman with Systemic Lupus Erythematosus (SLE), autoimmune haemolytic anaemia, periostitis, haematomas, bleeding leg ulcer and rectal haemorrhages; she had decreased levels of the prothrombin. Haemorrhagic episodes were related with the anti-prothrombin specificity of Lupus Anticoagulant (LA) detected. The SLE/LA/HPT association is less frequent than the correlated to SLE/LA/anti- ß2Glycoprotein I antibodies and was first reported in 1960 by Rapaport et al, in an 11-year- -old girl with severe haemorrhagic manifestations.

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How to Cite

1.
Campos MM, Reis Santos I. Hypoprothrombinemia--lupus anticoagulant syndrome. Acta Med Port [Internet]. 2011 Dec. 30 [cited 2024 Mar. 29];24:611-6. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1556

Issue

Section

Arquivo Histórico