Association between Serum Vitamin D and Diabetic Retinopathy in Portuguese Patients with Type 1 Diabetes

Authors

  • Miguel Lopes Faculty of Medicine. Porto University. Porto. https://orcid.org/0000-0002-7112-3580
  • Rita Laiginhas Faculty of Medicine. Porto University. Porto. Department of Ophthalmology. Centro Hospitalar de Entre o Douro e Vouga. Santa Maria da Feira. https://orcid.org/0000-0001-7275-6470
  • Carolina Madeira Department of Ophthalmology. Centro Hospitalar de São João. Porto.
  • João Sérgio Neves Department of Endocrinology, Diabetes and Metabolism. Centro Hospitalar de São João. Porto. Department of Surgery and Physiology. Faculty of Medicine. University of Porto. Porto. https://orcid.org/0000-0002-8173-8255
  • Margarida Barbosa Faculty of Medicine. Porto University. Porto. Department of Anesthesiology. Centro Hospitalar de São João. Porto. I3S Instituto de Investigação e Inovação em Saúde. University of Porto. Porto.
  • Vitor Rosas Department of Ophthalmology. Centro Hospitalar de São João. Porto.
  • Davide Carvalho Faculty of Medicine. Porto University. Porto. Department of Endocrinology, Diabetes and Metabolism. Centro Hospitalar de São João. Porto. https://orcid.org/0000-0002-3156-3741
  • Fernando Falcão-Reis Department of Ophthalmology. Centro Hospitalar de São João. Porto. Department of Surgery and Physiology. Faculty of Medicine. University of Porto. Porto.
  • Manuel Falcão Department of Ophthalmology. Centro Hospitalar de São João. Porto. Department of Surgery and Physiology. Faculty of Medicine. University of Porto. Porto. https://orcid.org/0000-0003-4718-0910

DOI:

https://doi.org/10.20344/amp.12890

Keywords:

Diabetes Mellitus, Type 1, Diabetic Retinopathy, Portugal, Vitamin D, Vitamin D Deficiency

Abstract

Introduction: Recently, vitamin D has gained importance as a diabetes risk modifier. Our aim was to assess the association between serum vitamin D levels and the prevalence of diabetic retinopathy in patients with type 1 diabetes.
Material and Methods: Retrospective review of a population of patients with type 1 diabetes followed in a Portuguese tertiary center. Patients were included if they had an ophthalmological evaluation and a serum 25-hydroxyvitamin D level determination within the same year. Logistic regression analysis was used to adjust for possible confounders.
Results: We included 182 patients (47% male), and 57% (n = 103) had signs of diabetic retinopathy. We found a significant association between lower circulating levels of 25-hydroxyvitamin D levels and a greater prevalence of diabetic retinopathy after adjusting for confounders (duration of diabetes, estimated glomerular filtration rate, age, sex, metabolic control, season, dyslipidemia and hypertension) (OR = 0.94; 95% CI 0.90 - 0.99, p = 0.023). Longer duration of diabetes and worse metabolic control also remained associated with diabetic retinopathy in the multivariate analysis (OR = 1.20; 95% CI 1.13 - 1.27, p < 0.001 and OR = 4.13; 95% CI 1.34 - 12.7, p = 0.013, respectively).
Conclusion: Lower levels of vitamin D were associated with an increased prevalence of diabetic retinopathy in patients with type 1 diabetes, after adjusting for possible confounders. Future controlled studies may elucidate the molecular routes for this association as well as the role of supplementation in the prevention of diabetes microvascular complications.

Downloads

Download data is not yet available.

Downloads

Published

2020-07-01

How to Cite

1.
Lopes M, Laiginhas R, Madeira C, Neves JS, Barbosa M, Rosas V, Carvalho D, Falcão-Reis F, Falcão M. Association between Serum Vitamin D and Diabetic Retinopathy in Portuguese Patients with Type 1 Diabetes. Acta Med Port [Internet]. 2020 Jul. 1 [cited 2022 Nov. 28];33(7-8):459-65. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/12890

Issue

Section

AMP Student Original