Human serum alcaline phosphatase and ageing.


  • M R Negrão Serviço de Bioquimica (U-38 FCT), Faculdade de Medicina, Universidade do Porto, Porto.
  • M J Martins
  • E Ramos
  • H Barros
  • C Hipólito-Reis
  • I Azevedo



In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed.To characterize serum levels of alkaline phosphatase activity in humans according to age and gender.Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years.In men (n=87) total serum alkaline phosphatase markedly increased from the 5th to the 6th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5th to the 6th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population.Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.


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How to Cite

Negrão MR, Martins MJ, Ramos E, Barros H, Hipólito-Reis C, Azevedo I. Human serum alcaline phosphatase and ageing. Acta Med Port [Internet]. 2003 Dec. 31 [cited 2023 Feb. 1];16(6):395-400. Available from:



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