Reninoma: A Rare Cause of Endocrine Hypertension

Authors

  • Bernardo Marques Serviço de Endocrinologia. Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE. Coimbra.
  • Joana Couto Serviço de Endocrinologia. Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE. Coimbra.
  • Manuel C. Lemos CICS-UBI, Centro de Investigação em Ciências da Saúde. Universidade da Beira Interior. Covilhã.
  • Fernando Rodrigues Serviço de Endocrinologia. Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE. Coimbra.

DOI:

https://doi.org/10.20344/amp.11660

Keywords:

Aldosterone, Hypertension/etiology, Juxtaglomerular Apparatus, Kidney Neoplasms, Renin

Abstract

Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 – 28 ng/dL), renin > 1000 mIU/mL (4.4 – 46.2 mIU/mL)]. Abdominal computed tomography scan identified a heterogeneous nodule located in the middle third of the right kidney, with 3.7 cm. Partial nephrectomy was performed and histological analysis confirmed the diagnosis of reninoma. After surgery, the patient had normal levels of aldosterone (9.2 ng/dL) and renin (1.20 mIU/mL), as well as normal blood pressure. The authors want to highlight this potentially curable cause of endocrine hypertension. Surgical resection is the treatment of choice and leads to normalization of blood pressure.

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Published

2020-12-02

How to Cite

1.
Marques B, Couto J, Lemos MC, Rodrigues F. Reninoma: A Rare Cause of Endocrine Hypertension. Acta Med Port [Internet]. 2020 Dec. 2 [cited 2024 Jul. 25];33(12):835-8. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/11660

Issue

Section

Case Report