A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer

Authors

  • Vera Clérigo Pulmonology – Thorax Department. Centro Hospitalar Lisboa Norte. Lisboa.
  • Ana Castro Pulmonary Diagnosis Center Dr. Ribeiro Sanches. Lisboa.
  • Teresa Mourato Pulmonary Diagnosis Center Dr. Ribeiro Sanches. Lisboa.
  • Conceição Gomes Pulmonary Diagnosis Center Dr. Ribeiro Sanches. Lisboa.

DOI:

https://doi.org/10.20344/amp.10250

Keywords:

BCG Vaccine, Granuloma/chemically induced, Pneumonia/chemically induced, Urinary Bladder Neoplasms/drug therapy

Abstract

Granulomatous pneumonitis is a rare complication of bacillus Calmette-Guerin immunotherapy following intravesical administration of bacillus Calmette-Guerin. The authors present an unusual case of a 67-year-old man who developed mild and non-specific symptoms, following intravesical bacillus Calmette-Guerin instillations. Examinations revealed features of miliary tuberculosis and granuloma suggestive of mycobacterial infection. Anti-tuberculosis treatment resulted in a remarkable improvement in his symptoms and gradually upgrading of radiological appearance. The symptoms were less severe than some others described but this case provides evidence that, even in some cases, specific treatment may be necessary. We highlight the importance of recognizing miliary Mycobacterium bovis as a probable complication of bacillus Calmette-Guerin immunotherapy. The clinical disease course can be mild, despite extensive bilateral miliary nodules on primary presentation.

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Published

2019-04-30

How to Cite

1.
Clérigo V, Castro A, Mourato T, Gomes C. A Rare Case of Granulomatous Pneumonitis Due to Intravesical BCG for Bladder Cancer. Acta Med Port [Internet]. 2019 Apr. 30 [cited 2024 Jun. 21];32(4):316-20. Available from: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10250

Issue

Section

Case Report