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Originals

Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees
O`Sullivan D;Brady N;Manning E;O`Shea E;O`Grady S;. Validation of the 6-Item Cognitive Impairment Test and the 4AT test for combined delirium and dementia screening in older Emergency Department attendees. Age Ageing. 2017 Sep 1:1-7. doi: 10.1093/ageing/afx149. (Original) PMID: 28985260

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«Tofacitinib is an oral Janus kinase inhibitor that is under investigation for the treatment of psoriatic arthritis. We evaluated tofacitinib in patients with active psoriatic arthritis who had previously had an inadequate response to tumor necrosis factor (TNF) inhibitors.»

Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial
Poonai N, Datoo N, Ali S, et al. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial. CMAJ. 2017 Oct 10;189(40):E1252-E1258. doi: 10.1503/cmaj.170017. (Original) PMID: 29018084

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«Oral morphine for postoperative pain after minor pediatric surgery, while increasingly popular, is not supported by evidence. We evaluated whether oral morphine was superior to ibuprofen for at-home management of children’s postoperative pain.»

Reviews

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease
Rankine-Mullings AE, Owusu-Ofori S. Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. Cochrane Database Syst Rev. 2017 Oct 10;10:CD003427. doi: 10.1002/14651858.CD003427.pub4. (Review) PMID: 28994899

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«Persons with sickle cell disease (SCD) are particularly susceptible to infection. Infants and very young children are especially vulnerable. The ‘Co-operative Study of Sickle Cell Disease’ observed an incidence rate for pneumococcal septicaemia of 10 per 100 person years in children under the age of three years. Vaccines, including customary pneumococcal vaccines, may be of limited use in this age group. Therefore, prophylactic penicillin regimens may be advisable for this population. This is an update of a Cochrane Review first published in 2002, and previously updated, most recently in 2014.»

Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants
Shah SS, Ohlsson A, Halliday HL, et al. Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants. Cochrane Database Syst Rev. 2017 Oct 16;10:CD002057. doi: 10.1002/14651858.CD002057.pub4. (Review) PMID: 29035425

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«To compare the effectiveness of inhaled versus systemic corticosteroids administered to ventilator-dependent preterm neonates with birth weight ≤ 1500 g or gestational age ≤ 32 weeks after 7 days of life on the incidence of death or BPD at 36 weeks’ postmenstrual age.»

Evidence-based guidelines for supportive care of patients with Ebola virus disease
Lamontagne F;Fowler RA;Adhikari NK;Murthy S;Brett-. Evidence-based guidelines for supportive care of patients with Ebola virus disease. Lancet. 2017 Oct 17. pii: S0140-6736(17)31795-6. doi: 10.1016/S0140-6736(17)31795-6. (Review) PMID: 29054555

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«Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients’ reluctance to present for medical care, and limitations in the provision of supportive medical care.»