XXVI Highlights AMP-S

      No Comments on XXVI Highlights AMP-S

Originals

Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa
Hakim J, Musiime V, Szubert AJ, et al. Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa. N Engl J Med. 2017 Jul 20;377(3):233-245. doi: 10.1056/NEJMoa1615822. (Original) PMID: 28723333

Photo: Shuttershock

«In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%.»

Trial of Tocilizumab in Giant-Cell Arteritis
Stone JH, Tuckwell K, Dimonaco S, et al. Trial of Tocilizumab in Giant-Cell Arteritis. N Engl J Med. 2017 Jul 27;377(4):317-328. doi: 10.1056/NEJMoa1613849. (Original) PMID: 28745999

Photo: Shuttershock

«Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis.»

Reviews

Effectiveness of Tympanostomy Tubes for Otitis Media: A Meta-analysis
Steele DW, Adam GP, Di M, et al. Effectiveness of Tympanostomy Tubes for Otitis Media: A Meta-analysis. Pediatrics. 2017 May 16. pii: e20170125. doi: 10.1542/peds.2017-0125. (Review) PMID: 28562283

Photo: Shuttershock

«Tympanostomy tube placement is the most common ambulatory surgery performed on children in the United States.»

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review
Frank JW, Lovejoy TI, Becker WC, et al. Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review. Ann Intern Med. 2017 Aug 1;167(3):181-191. doi: 10.7326/M17-0598. Epub 2017 Jul 11. (Review) PMID: 28715848

Photo: Shuttershock

«Expert guidelines recommend reducing or discontinuing long-term opioid therapy (LTOT) when risks outweigh benefits, but evidence on the effect of dose reduction on patient outcomes has not been systematically reviewed.»