XIX Highlights AMP-S

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Originals

Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study
Abraham NS, Noseworthy PA, Yao X, et al. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study. Gastroenterology. 2017 Apr;152(5):1014-1022.e1. doi: 10.1053/j.gastro.2016.12.018. Epub 2016 Dec 30. (Original) PMID: 28043907

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«Direct oral anticoagulant (DOAC) agents increase the risk of gastrointestinal (GI) bleeding. We investigated which DOAC had the most favorable GI safety profile and compared differences among these drugs in age-related risk of GI bleeding.»

Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement
Bibbins-Domingo K, Grossman DC, Curry SJ, et al. Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement. JAMA. 2017 Apr 25;317(16):1661-1667. doi: 10.1001/jama.2017.3439. (Review) PMID: 28444286

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«Preeclampsia affects approximately 4% of pregnancies in the United States. It is the second leading cause of maternal mortality worldwide and may lead to serious maternal complications, including stroke, eclampsia, and organ failure. Adverse perinatal outcomes for the fetus and newborn include intrauterine growth restriction, low birth weight, and stillbirth. Many of the complications associated with preeclampsia lead to early induction of labor or cesarean delivery and subsequent preterm birth.»

Reviews

Treatment Guidelines for Rheumatologic Manifestations of Sjogren`s Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain
Carsons SE, Vivino FB, Parke A, et al. Treatment Guidelines for Rheumatologic Manifestations of Sjogren`s Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain. Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-527. doi: 10.1002/acr.22968. Epub 2017 Mar 3. (Review) PMID: 27390247

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«The Sjögren’s Syndrome Foundation clinical practice guidelines (CPGs) are designed to improve quality and consistency of care in Sjögren’s syndrome by offering recommendations for management.»

Aspirin and Risk of Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis
Phan K, Moore JM, Griessenauer CJ, et al. Aspirin and Risk of Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis. Stroke. 2017 May;48(5):1210-1217. doi: 10.1161/STROKEAHA.116.015674. Epub 2017 Mar 24. (Review) PMID: 28341753

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«Recent studies have suggested that the use of low-dose aspirin may reduce the risk of aneurysmal subarachnoid hemorrhage (aSAH). We aimed to evaluate any association between aspirin use and risk of aSAH based on the literature, and whether this is influenced by duration or frequency of aspirin use.»

Use of antibiotics during pregnancy and risk of spontaneous abortion
Muanda FT, Sheehy O, Berard A. Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ. 2017 May 1;189(17):E625-E633. doi: 10.1503/cmaj.161020. (Original) PMID: 28461374

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«Although antibiotics are widely used during pregnancy, evidence regarding their fetal safety remains limited. Our aim was to quantify the association between antibiotic exposure during pregnancy and risk of spontaneous abortion.»